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Gene-Targeted Deletion of Neurofibromin Enhances the Expression of a Transient Outward K(+) Current in Schwann Cells: A Protein Kinase A-Mediated Mechanism
Mutations in the neurofibromatosis type 1 gene predispose patients to develop benign peripheral nerve tumors (neurofibromas) containing Schwann cells (SCs). SCs from neurofibromatosis type-1 gene (Nf1) null mutant mice showed increased levels of Ras-GTP and cAMP. The proliferation and differentiatio...
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| Publicado no: | J Neurosci |
|---|---|
| Principais autores: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6758039/ https://ncbi.nlm.nih.gov/pubmed/12417644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-21-09194.2002 |
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