Limbic Seizures Induce P-Glycoprotein in Rodent Brain: Functional Implications for Pharmacoresistance

The causes and mechanisms underlying multidrug resistance (MDR) in epilepsy are still elusive and may depend on inadequate drug concentration in crucial brain areas. We studied whether limbic seizures or anticonvulsant drug treatments in rodents enhance the brain expression of the MDR gene (mdr) enc...

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Publié dans:J Neurosci
Auteurs principaux: Rizzi, Massimo, Caccia, Silvio, Guiso, Giovanna, Richichi, Cristina, Gorter, Jan A., Aronica, Eleonora, Aliprandi, Marisa, Bagnati, Renzo, Fanelli, Roberto, D'Incalci, Maurizio, Samanin, Rosario, Vezzani, Annamaria
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2002
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ARTICLE
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6757954/
https://ncbi.nlm.nih.gov/pubmed/12122045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-14-05833.2002
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