Multiple Channel Interactions Explain the Protection of Sympathetic Neurons from Apoptosis Induced by Nerve Growth Factor Deprivation

We investigated the neuroprotective properties of two M-type K(+) channel blockers, linopirdine and its analog XE991, in rat sympathetic neurons deprived of nerve growth factor (NGF). Linopirdine and XE991 promoted sympathetic neuronal survival 48–72 hr after NGF withdrawal in a concentration-depend...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Xia, Shuli, Lampe, Patricia A., Deshmukh, Mohanish, Yang, Aizhen, Brown, Barry S., Rothman, Steve M., Johnson, Eugene M., Yu, Shan Ping
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2002
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6757625/
https://ncbi.nlm.nih.gov/pubmed/11756494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-01-00114.2002
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