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PU-91 drug rescues human age-related macular degeneration RPE cells; implications for AMD therapeutics
Since mitochondrial dysfunction is implicated in the pathogenesis of AMD, this study is based on the premise that repurposing of mitochondria-stabilizing FDA-approved drugs such as PU-91, might rescue AMD RPE cells from AMD mitochondria-induced damage. The PU-91 drug upregulates PGC-1α which is a cr...
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| Publicado no: | Aging (Albany NY) |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6756897/ https://ncbi.nlm.nih.gov/pubmed/31477635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102179 |
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