Blood and skin-derived Sezary cells: differences in proliferation-index, activation of PI3K/AKT/mTORC1 pathway and its prognostic relevance

Sézary syndrome (SS) is a rare and aggressive variant of Cutaneous T-Cell Lymphoma characterized by neoplastic distribution mainly involving blood, skin, and lymph-node. Although a role of the skin microenvironment in SS pathogenesis has long been hypothesized, its function in vivo is poorly charact...

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Publicado en:Leukemia
Autores principales: Cristofoletti, Cristina, Bresin, Antonella, Picozza, Mario, Picchio, Maria Cristina, Monzo, Francesca, Helmer Citterich, Mauro, Passarelli, Francesca, Frezzolini, Alessandra, Scala, Enrico, Monopoli, Alessandro, Cantonetti, Maria, Benucci, Roberto, D’Atri, Stefania, Caprini, Elisabetta, Russo, Giandomenico, Narducci, Maria Grazia
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756225/
https://ncbi.nlm.nih.gov/pubmed/30518812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0305-8
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