Emodin sensitizes human pancreatic cancer cells to EGFR inhibitor through suppressing Stat3 signaling pathway

BACKGROUND: Excessive expression of EGFR is closely related to tumor formation, transfer and deterioration, which has attracted much attention. EGFR overexpression may be detected in up to 90% of pancreatic tumors. However, drug resistance of EGFR inhibitors targeting treatment severely limits its c...

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Bibliografske podrobnosti
izdano v:Cancer Manag Res
Main Authors: Wang, Zhaohong, Chen, Hui, Chen, Jingjing, Hong, Zhong, Liao, Yi, Zhang, Qiyu, Tong, Hongfei
Format: Artigo
Jezik:Inglês
Izdano: Dove 2019
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756157/
https://ncbi.nlm.nih.gov/pubmed/31572001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S221877
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