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Sumoylation of Flotillin-1 promotes EMT in metastatic prostate cancer by suppressing Snail degradation
Flotillin-1 (Flot-1) has been shown to regulate cancer progression, but the regulatory role of post-translational modifications of Flot-1 on cancers remains elusive. Herein, we show that up-regulated E2 conjugating enzyme UBC9 sumoylates Flot-1 at Lys-51 and Lys-195 with small ubiquitin-like modifie...
Tallennettuna:
| Julkaisussa: | Oncogene |
|---|---|
| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group UK
2019
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6756018/ https://ncbi.nlm.nih.gov/pubmed/30631151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0641-1 |
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