Clofarabine-phytochemical combination exposures in CML cells inhibit DNA methylation machinery, upregulate tumor suppressor genes and promote caspase-dependent apoptosis

Clofarabine (2-chloro-2′-fluoro-2′-deoxyarabinosyladenine, CIF), a second-generation 2′-deoxyadenosine analog, possesses a variety of anti-cancer activities, including the capacity to modulate DNA methylation marks. Bioactive nutrients, including resveratrol (RSV) and all-trans retinoic acid (ATRA)...

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Publicado en:Mol Med Rep
Main Authors: Kaufman-Szymczyk, Agnieszka, Majda, Katarzyna, Szuławska-Mroczek, Agata, Fabianowska-Majewska, Krystyna, Lubecka, Katarzyna
Formato: Artigo
Idioma:Inglês
Publicado: D.A. Spandidos 2019
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6755200/
https://ncbi.nlm.nih.gov/pubmed/31485618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2019.10619
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