Interleukin-1 causes CNS inflammatory cytokine expression via endothelia-microglia bi-cellular signaling

As a major producer of the inflammatory cytokine interleukin-1 (IL-1), peripheral macrophages can augment IL-1 expression via type 1 IL-1 receptor (IL-1R1) mediated autocrine self-amplification. In the CNS, microglial cells are the major producers of inflammatory cytokines, but express negligible le...

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Detalhes bibliográficos
Publicado no:Brain Behav Immun
Main Authors: Zhu, Ling, Liu, Xiaoyu, Nemeth, Daniel P., DiSabato, Damon J., Witcher, Kristina G., Mckim, Daniel B., Oliver, Braedan, Le, Xi, Gorantla, Gowthami, Berdysz, Olimpia, Li, Jiaoni, Ramani, Aishwarya D., Chen, Zhibiao, Wu, Dongcheng, Godbout, Jonathan P., Quan, Ning
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754782/
https://ncbi.nlm.nih.gov/pubmed/31228609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2019.06.026
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