Myelin Oligodendrocyte Glycoprotein-IgG Contributes to Oligodendrocytopathy in the Presence of Complement, Distinct from Astrocytopathy Induced by AQP4-IgG

Immunoglobulin G against myelin oligodendrocyte glycoprotein (MOG-IgG) is detectable in neuromyelitis optica spectrum disorder (NMOSD) without aquaporin-4 IgG (AQP4-IgG), but its pathogenicity remains unclear. In this study, we explored the pathogenic mechanisms of MOG-IgG in vitro and in vivo and c...

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Veröffentlicht in:Neurosci Bull
Hauptverfasser: Fang, Ling, Kang, Xinmei, Wang, Zhen, Wang, Shisi, Wang, Jingqi, Zhou, Yifan, Chen, Chen, Sun, Xiaobo, Yan, Yaping, Kermode, Allan G., Peng, Lisheng, Qiu, Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Singapore 2019
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754494/
https://ncbi.nlm.nih.gov/pubmed/31041694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12264-019-00375-8
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