Haploinsufficiency of Transferrin Receptor 1 Impairs Angiogenesis with Reduced Mitochondrial Complex I in Mice with Limb Ischemia

Limb ischemia (LI) is a major consequence of peripheral artery disease (PAD) with a high mortality rate. Iron is an essential mineral to maintain physiological function of multiple organs. Intracellular iron transport is regulated by transferrin receptor 1 (TfR1). Although increase in serum ferritin...

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Udgivet i:Sci Rep
Main Authors: Okuno, Keisuke, Naito, Yoshiro, Yasumura, Seiki, Sawada, Hisashi, Asakura, Masanori, Masuyama, Tohru, Ishihara, Masaharu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754437/
https://ncbi.nlm.nih.gov/pubmed/31541184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49983-4
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