Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade

MicroRNAs (miRs) downregulate or upregulate the mRNA level by binding to the 3′-untranslated region (3′UTR) of target gene. Dysregulated miR levels can be used as biomarkers of Parkinson’s disease (PD) and could participate in the etiology of PD. In the present study, 45 brain-enriched miRs were eva...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Chiu, Ching-Chi, Yeh, Tu-Hsueh, Chen, Rou-Shayn, Chen, Hua-Chien, Huang, Ying-Zu, Weng, Yi-Hsin, Cheng, Yi-Chuan, Liu, Yu-Chuan, Cheng, Ann-Joy, Lu, Ya-Ching, Chen, Yu-Jie, Lin, Yan-Wei, Hsu, Chia-Chen, Chen, Ying-Ling, Lu, Chin-Song, Wang, Hung-Li
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753175/
https://ncbi.nlm.nih.gov/pubmed/31572127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00399
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