The specific seroreactivity to ∆Np73 isoforms shows higher diagnostic ability in colorectal cancer patients than the canonical p73 protein

The p53-family is tightly regulated at transcriptional level. Due to alternative splicing, up to 40 different theoretical proteoforms have been described for p73 and at least 20 and 10 for p53 and p63, respectively. However, only the canonical proteins have been evaluated as autoantibody targets in...

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Vydáno v:Sci Rep
Hlavní autoři: Garranzo-Asensio, María, Guzmán-Aránguez, Ana, Povés, Carmen, Fernández-Aceñero, María Jesús, Montero-Calle, Ana, Ceron, María Ángeles, Fernandez-Diez, Servando, Rodríguez, Nuria, Gómez de Cedrón, Marta, Ramírez de Molina, Ana, Domínguez, Gemma, Barderas, Rodrigo
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753153/
https://ncbi.nlm.nih.gov/pubmed/31537884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49960-x
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