Discovering genetic interactions bridging pathways in genome-wide association studies

Genetic interactions have been reported to underlie phenotypes in a variety of systems, but the extent to which they contribute to complex disease in humans remains unclear. In principle, genome-wide association studies (GWAS) provide a platform for detecting genetic interactions, but existing metho...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Fang, Gang, Wang, Wen, Paunic, Vanja, Heydari, Hamed, Costanzo, Michael, Liu, Xiaoye, Liu, Xiaotong, VanderSluis, Benjamin, Oately, Benjamin, Steinbach, Michael, Van Ness, Brian, Schadt, Eric E., Pankratz, Nathan D., Boone, Charles, Kumar, Vipin, Myers, Chad L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753138/
https://ncbi.nlm.nih.gov/pubmed/31537791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12131-7
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