The N-Acetyl Phenylalanine Glucosamine Derivative Attenuates the Inflammatory/Catabolic Environment in a Chondrocyte-Synoviocyte Co-Culture System

Osteoarthritis (OA), the most prevalent degenerative joint disease, still lacks a true disease-modifying therapy. The involvement of the NF-κB pathway and its upstream activating kinases in OA pathogenesis has been recognized for many years. The ability of the N-acetyl phenylalanine glucosamine deri...

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Udgivet i:Sci Rep
Main Authors: Pagani, Stefania, Minguzzi, Manuela, Sicuro, Laura, Veronesi, Francesca, Santi, Spartaco, Scotto D’Abusco, Anna, Fini, Milena, Borzì, Rosa Maria
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753094/
https://ncbi.nlm.nih.gov/pubmed/31537813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49188-9
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