Targeting Cardiac Fibrosis with Engineered T cells

Fibrosis is observed in nearly every form of myocardial disease(1). Upon injury, cardiac fibroblasts (CF) in the heart begin to remodel the myocardium via extracellular matrix deposition, resulting in increased tissue stiffness and reduced compliance. Excessive cardiac fibrosis is an important facto...

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Publicat a:Nature
Autors principals: Aghajanian, Haig, Kimura, Toru, Rurik, Joel G., Hancock, Aidan S., Leibowitz, Michael S., Li, Li, Scholler, John, Monslow, James, Lo, Albert, Han, Wei, Wang, Tao, Bedi, Kenneth, Morley, Michael P., Saldana, Ricardo A. Linares, Bolar, Nikhita A., McDaid, Kendra, Assenmacher, Charles-Antoine, Smith, Cheryl L., Wirth, Dagmar, June, Carl H., Margulies, Kenneth B., Jain, Rajan, Puré, Ellen, Albelda, Steven M., Epstein, Jonathan A.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6752964/
https://ncbi.nlm.nih.gov/pubmed/31511695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1546-z
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