Combination of trastuzumab emtansine and stereotactic radiosurgery results in high rates of clinically significant radionecrosis and dysregulation of Aquaporin-4.

PURPOSE: Patients with human epidermal growth factor receptor 2-positive (HER2+) breast cancer have a high incidence of brain metastases, and trastuzumab emtansine (T-DM1) is often employed. Stereotactic radiosurgery (SRS) is frequently utilized, and case series report increased toxicity with combin...

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Pubblicato in:Clin Cancer Res
Autori principali: Stumpf, Priscilla K., Cittelly, Diana M., Robin, Tyler P., Carlson, Julie A., Stuhr, Kelly A., Contreras-Zarate, Maria Jose, Lai, Steven, Ormond, D. Ryan, Rusthoven, Chad G., Gaspar, Laurie E., Rabinovitch, Rachel, Kavanagh, Brian D., Liu, Arthur, Diamond, Jennifer, Kabos, Peter, Fisher, Christine M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6751332/
https://ncbi.nlm.nih.gov/pubmed/30940654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2851
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