Deactivation of ATP-Binding Cassette Transporters ABCB1 and ABCC1 Does Not Influence Post-ischemic Neurological Deficits, Secondary Neurodegeneration and Neurogenesis, but Induces Subtle Microglial Morphological Changes

ATP-binding cassette (ABC) transporters prevent the access of pharmacological compounds to the ischemic brain, thereby impeding the efficacy of stroke therapies. ABC transporters can be deactivated by selective inhibitors, which potently increase the brain accumulation of drugs. Concerns have been r...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Manrique-Castano, Daniel, Sardari, Maryam, Silva de Carvalho, Tayana, Doeppner, Thorsten R., Popa-Wagner, Aurel, Kleinschnitz, Christoph, Chan, Andrew, Hermann, Dirk M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6751309/
https://ncbi.nlm.nih.gov/pubmed/31572128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00412
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