Antibiotics-driven gut microbiome perturbation alters immunity to vaccines in humans

Emerging evidence indicates a central role for the microbiome in immunity. However, causal evidence in humans is sparse. Here we administered broad spectrum antibiotics to healthy adults prior and subsequent to seasonal influenza vaccination. Despite a 10,000-fold reduction in gut bacterial load and...

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Publicado no:Cell
Main Authors: Hagan, Thomas, Cortese, Mario, Rouphael, Nadine, Boudreau, Carolyn, Linde, Caitlin, Maddur, Mohan S., Das, Jishnu, Wang, Hong, Guthmiller, Jenna, Zheng, Nai-Ying, Huang, Min, Uphadhyay, Amit A., Gardinassi, Luiz, Petitdemange, Caroline, McCullough, Michele Paine, Johnson, Sara Jo, Gill, Kiran, Cervasi, Barbara, Zou, Jun, Bretin, Alexis, Hahn, Megan, Gewirtz, Andrew T., Bosinger, Steve E., Wilson, Patrick C., Li, Shuzhao, Alter, Galit, Khurana, Surender, Golding, Hana, Pulendran, Bali
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750738/
https://ncbi.nlm.nih.gov/pubmed/31491384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.08.010
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