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Calyciphylline B-Type Alkaloids: Total Syntheses of (−)-Daphlongamine H and (−)-Isodaphlongamine H

The first total synthesis of the complex hexacylic Daphniphyllum alkaloid (−)-daphlongamine H has been accomplished. Key to the success of the strategy are a complexity-building Mannich reaction, efficient cyclizations, and a highly diastereoselective hydrogenation to assemble multigram quantities o...

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Pubblicato in:J Am Chem Soc
Autori principali: Hugelshofer, Cedric L., Palani, Vignesh, Sarpong, Richmond
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750003/
https://ncbi.nlm.nih.gov/pubmed/31074980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b03576
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