12-lipoxygenase promotes tumor progress by TGF-β1-mediated epithelial to mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma

PURPOSE: To clarify the effect of 12-lipoxygenase/12-hydroxyeicosatetraeonic acid (12-LOX/12-HETE) on progress of esophageal squamous cell carcinoma (ESCC) and the possible mechanism. PATIENTS AND METHODS: We performed cell experiments including chemical treatment, transfection, Western blotting and...

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Publicat a:Cancer Manag Res
Autors principals: Qu, Yan, Wen, Zhihua, Mi, Si, Chen, Pengxiang, Wang, Jianbo, Jia, Yibin, Cheng, Yufeng
Format: Artigo
Idioma:Inglês
Publicat: Dove 2019
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6749984/
https://ncbi.nlm.nih.gov/pubmed/31571988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S212478
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