Reversal of Surfactant Protein B Deficiency in Patient Specific Human Induced Pluripotent Stem Cell Derived Lung Organoids by Gene Therapy

Surfactant protein B (SFTPB) deficiency is a fatal disease affecting newborn infants. Surfactant is produced by alveolar type II cells which can be differentiated in vitro from patient specific induced pluripotent stem cell (iPSC)-derived lung organoids. Here we show the differentiation of patient s...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Leibel, Sandra Lawrynowicz, Winquist, Alicia, Tseu, Irene, Wang, Jinxia, Luo, Daochun, Shojaie, Sharareh, Nathan, Neal, Snyder, Evan, Post, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748939/
https://ncbi.nlm.nih.gov/pubmed/31530844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49696-8
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