Engineering an anti-CD52 antibody for enhanced deamidation stability

Deamidation evaluation and mitigation is an important aspect of therapeutic antibody developability assessment. We investigated the structure and function of the Asn-Gly deamidation in a human anti-CD52 IgG1 antibody light chain complementarity-determining region 1, and risk mitigation through prote...

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Bibliografske podrobnosti
izdano v:MAbs
Main Authors: Qiu, Huawei, Wei, Ronnie, Jaworski, Julie, Boudanova, Ekaterina, Hughes, Heather, VanPatten, Scott, Lund, Anders, Day, Jaime, Zhou, Yanfeng, McSherry, Tracey, Pan, Clark Q., Sendak, Rebecca
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2019
Teme:
Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748592/
https://ncbi.nlm.nih.gov/pubmed/31199181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1631117
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