BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is characterized by the accumulation of Langerin (CD207)-expressing histiocytes. Mutational activation of mitogen-activated protein kinase pathway genes, in particular BRAF, drives most cases. To test whether activated BRAF is sufficient for the development of LCH...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Nelson, David S., Marano, Ryan L., Joo, Yechaan, Tian, Sara Y., Patel, Bhumi, Kaplan, Daniel H., Shlomchik, Mark J., Stevenson, Kristen, Bronson, Roderick T., Rollins, Barrett J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748438/
https://ncbi.nlm.nih.gov/pubmed/31527903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0222400
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