PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age

BACKGROUND: PNPLA3 rs738409 minor allele c.444G represents a risk factor for liver steatosis and fibrosis progression also in chronic hepatitis C (HCV). We investigated its impact on the timing of liver transplantation (LT) in patients with genotype 1b HCV cirrhosis. METHODS: We genotyped and evalua...

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Veröffentlicht in:PLoS One
Hauptverfasser: Senkerikova, Renata, Frankova, Sona, Jirsa, Milan, Kreidlova, Miluse, Merta, Dusan, Neroldova, Magdalena, Chmelova, Klara, Spicak, Julius, Sperl, Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748417/
https://ncbi.nlm.nih.gov/pubmed/31527889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0222609
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