Type I Interferon Therapy Limits CNS Autoimmunity by Inhibiting CXCR3-Mediated Trafficking of Pathogenic Effector T Cells

Type I interferons (IFNs) have therapeutic potential in CNS autoimmune diseases, such as uveitis, but the molecular mechanisms remain unclear. Using a T cell-transfer model of experimental autoimmune uveitis (EAU), we found that IFN-α/β treatment inhibited the migration of IFN-γ-producing pathogenic...

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Publicado no:Cell Rep
Main Authors: Wang, Weiwei, Chong, Wai Po, Li, Chunmei, Chen, Zilin, Wu, Sihan, Zhou, Hongyan, Wan, Ying, Chen, Wanjun, Gery, Igal, Liu, Yizhi, Caspi, Rachel R., Chen, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748389/
https://ncbi.nlm.nih.gov/pubmed/31291583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.06.021
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