Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation

In the presence of aggregation-prone proteins, the cytosol and endoplasmic reticulum (ER) undergo a dramatic shift in their respective redox status, with the cytosol becoming more oxidized and the ER more reducing. However, whether and how changes in the cellular redox status may affect protein aggr...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Guerrero-Gómez, David, Mora-Lorca, José Antonio, Sáenz-Narciso, Beatriz, Naranjo-Galindo, Francisco José, Muñoz-Lobato, Fernando, Parrado-Fernández, Cristina, Goikolea, Julen, Cedazo-Minguez, Ángel, Link, Christopher D., Neri, Christian, Sequedo, María Dolores, Vázquez-Manrique, Rafael P., Fernández-Suárez, Elena, Goder, Veit, Pané, Roser, Cabiscol, Elisa, Askjaer, Peter, Cabello, Juan, Miranda-Vizuete, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748101/
https://ncbi.nlm.nih.gov/pubmed/30770874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0270-9
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