Conditional deletion of platelet derived growth factor receptor alpha (Pdgfra) in urorectal mesenchyme causes mesenchyme apoptosis and urorectal developmental anomalies in mice

In mammals, urorectal development starts at early embryonic stage, defective urorectal development results in anorectal malformations, which are common congenital developmental defects of the anus and the urethra in newborns. The etiology and embryology of the defects are still largely unknown. Plat...

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Veröffentlicht in:Cell Death Differ
Hauptverfasser: Qian, Chen, Wu, Zhongluan, Ng, Roy Chun-Laam, Garcia-Barceló, Maria-Mercè, Yuan, Zheng-Wei, Wong, Kenneth Kak Yuen, Tam, Paul Kwong Hang, Lui, Vincent Chi Hang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748092/
https://ncbi.nlm.nih.gov/pubmed/30323271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0216-2
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