Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma

Natural killer/T cell lymphoma (NKTCL) is a rare and aggressive malignancy with a higher prevalence in Asia and South America. However, the molecular genetic mechanisms underlying NKTCL remain unclear. Here, we identify somatic mutations of GNAQ (encoding the T96S alteration of Gαq protein) in 8.7%...

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Pubblicato in:Nat Commun
Autori principali: Li, Zhaoming, Zhang, Xudong, Xue, Weili, Zhang, Yanjie, Li, Chaoping, Song, Yue, Mei, Mei, Lu, Lisha, Wang, Yingjun, Zhou, Zhiyuan, Jin, Mengyuan, Bian, Yangyang, Zhang, Lei, Wang, Xinhua, Li, Ling, Li, Xin, Fu, Xiaorui, Sun, Zhenchang, Wu, Jingjing, Nan, Feifei, Chang, Yu, Yan, Jiaqin, Yu, Hui, Feng, Xiaoyan, Wang, Guannan, Zhang, Dandan, Fu, Xuefei, Zhang, Yuan, Young, Ken H., Li, Wencai, Zhang, Mingzhi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746819/
https://ncbi.nlm.nih.gov/pubmed/31527657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12032-9
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