Hypoxic ER stress suppresses β-catenin expression and promotes cooperation between the transcription factors XBP1 and HIF1α for cell survival

Hypoxia occurs in many human solid tumors and activates multiple cellular adaptive-response pathways, including the unfolded protein response (UPR) in the endoplasmic reticulum (ER). Wnt/β-catenin signaling plays a critical role in tumorigenesis, and β-catenin has been shown to enhance hypoxia-induc...

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Vydáno v:J Biol Chem
Hlavní autoři: Xia, Zhixiong, Wu, Shiyong, Wei, Xin, Liao, Yifei, Yi, Ping, Liu, Yong, Liu, Jianmiao, Liu, Jianfeng
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746444/
https://ncbi.nlm.nih.gov/pubmed/31350332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008353
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