Structure-based optimization of a PDZ-binding motif within a viral peptide stimulates neurite outgrowth

Protection of neuronal homeostasis is a major goal in the management of neurodegenerative diseases. Microtubule-associated Ser/Thr kinase 2 (MAST2) inhibits neurite outgrowth, and its inhibition therefore represents a potential therapeutic strategy. We previously reported that a viral protein (G-pro...

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Vydáno v:J Biol Chem
Hlavní autoři: Khan, Zakir, Terrien, Elouan, Delhommel, Florent, Lefebvre-Omar, Cynthia, Bohl, Delphine, Vitry, Sandrine, Bernard, Clara, Ramirez, Juan, Chaffotte, Alain, Ricquier, Kevin, Vincentelli, Renaud, Buc, Henri, Prehaud, Christophe, Wolff, Nicolas, Lafon, Monique
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746437/
https://ncbi.nlm.nih.gov/pubmed/31346033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008238
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