Development of a Water-Soluble Indolylmaleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis

[Image: see text] The indolylmaleimide (IM) derivative IM-17 shows inhibitory activity against oxidative-stress-induced necrotic cell death and cardioprotective activity in rat ischemia-reperfusion injury models. In order to develop a more potent derivative, we conducted a detailed structure–activit...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Dodo, Kosuke, Kuboki, Erika, Shimizu, Tadashi, Imamura, Ryu, Magarisawa, Megumi, Takahashi, Masahiro, Tokuhiro, Takuto, Yotsumoto, Satoshi, Asano, Kenichi, Nakao, Shuhei, Terayama, Naoki, Suda, Takashi, Tanaka, Masato, Sodeoka, Mikiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746101/
https://ncbi.nlm.nih.gov/pubmed/31531196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00142
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