Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver microsomes

In this study, we used reporter gene assays in COS-1 cells to examine the activation of rat pregnane X receptor (PXR), rat constitutive androstane receptor (CAR) and rat peroxisome-proliferator activated receptor (PPAR)α by pyrethroid pesticides, and to understand the effects of metabolic modificati...

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Publicat a:Heliyon
Autors principals: Fujino, Chieri, Watanabe, Yoko, Sanoh, Seigo, Nakajima, Hiroyuki, Uramaru, Naoto, Kojima, Hiroyuki, Yoshinari, Kouichi, Ohta, Shigeru, Kitamura, Shigeyuki
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6745485/
https://ncbi.nlm.nih.gov/pubmed/31538121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2019.e02466
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