Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes

The potential for cardiotoxicity is carefully evaluated for pharmaceuticals, as it is a major safety liability. However, environmental chemicals are seldom tested for their cardiotoxic potential. Moreover, there is a large variability in both baseline and drug-induced cardiovascular risk in humans,...

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Pubblicato in:Toxicol Appl Pharmacol
Autori principali: Burnett, Sarah D., Blanchette, Alexander D., Grimm, Fabian A., House, John S., Reif, David M., Wright, Fred A., Chiu, Weihsueh A., Rusyn, Ivan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6745256/
https://ncbi.nlm.nih.gov/pubmed/31425687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2019.114711
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