An in situ high-throughput screen identifies inhibitors of intracellular Burkholderia pseudomallei with therapeutic efficacy

Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm) are Tier-1 Select Agents that cause melioidosis and glanders, respectively. These are highly lethal human infections with limited therapeutic options. Intercellular spread is a hallmark of Burkholderia pathogenesis, and its prominent ties t...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Bulterys, Philip L., Toesca, Isabelle J., Norris, Michael H., Maloy, Jeffrey P., Fitz-Gibbon, Sorel T., France, Bryan, Toffig, Babak, Morselli, Marco, Somprasong, Nawarat, Pellegrini, Matteo, Schweizer, Herbert P., Tuanyok, Apichai, Damoiseaux, Robert, French, Christopher T., Miller, Jeff F.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744847/
https://ncbi.nlm.nih.gov/pubmed/31439817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906388116
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