HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs

Maintenance of high-turnover tissues such as the epidermis requires a balance between stem cell proliferation and differentiation. The molecular mechanisms governing this process are an area of investigation. Here we show that HNRNPK, a multifunctional protein, is necessary to prevent premature diff...

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Pubblicato in:Nat Commun
Autori principali: Li, Jingting, Chen, Yifang, Xu, Xiaojun, Jones, Jackson, Tiwari, Manisha, Ling, Ji, Wang, Ying, Harismendy, Olivier, Sen, George L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744489/
https://ncbi.nlm.nih.gov/pubmed/31519929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12238-x
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