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SORL1基因敲除小鼠可作为散发性阿尔茨海默病模型
OBJECTIVE: To compare the behavioral and pathological features of SORL1 gene knockout mice with those of normal mice and APP/PSE1 mice to verify the feasibility of using SORL1 knockout mice as a model of sporadic Alzheimer disease. METHODS: SORL1 gene of fertilized mouse eggs were edited using Crisp...
Gardado en:
| Publicado en: | Nan Fang Yi Ke Da Xue Xue Bao |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
南方医科大学学报编辑部
2018
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6744166/ https://ncbi.nlm.nih.gov/pubmed/29643034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3969/j.issn.1673-4254.2018.03.08 |
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