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Defective Collagen Binding and Increased Bleeding in a Murine Model of von Willebrand Disease Affecting Collagen IV Binding
SUMMARY: BACKGROUND: Von Willebrand factor (VWF) binding to type IV collagen occurs via the VWF A1 domain, with p.R1399H the most common VWF variant affecting this interaction. OBJECTIVES: We generated a murine model of 1399H VWF to investigate its in vivo effects. METHODS: Mice expressing the murin...
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| Publicado en: | J Thromb Haemost |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6743498/ https://ncbi.nlm.nih.gov/pubmed/30565388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14341 |
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