BRD4 Inhibitor AZD5153 Suppresses the Proliferation of Colorectal Cancer Cells and Sensitizes the Anticancer Effect of PARP Inhibitor

Background: Bromodomain-containing protein 4(BRD4) is reported to play a vital role in the development of numerous malignant diseases, which is considered as a promising target for cancer therapy. AZD5153, a novel specific BRD4 inhibitor, showed potent anticancer effects in several cancer types, but...

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Опубликовано в: :Int J Biol Sci
Главные авторы: Zhang, Peng, Li, Ruidong, Xiao, Hua, Liu, Weizhen, Zeng, Xiangyu, Xie, Genchen, Yang, Wenchang, Shi, Liang, Yin, Yuping, Tao, Kaixiong
Формат: Artigo
Язык:Inglês
Опубликовано: Ivyspring International Publisher 2019
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6743290/
https://ncbi.nlm.nih.gov/pubmed/31523195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.34162
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