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Quantitative MNase-seq accurately maps nucleosome occupancy levels
Micrococcal nuclease (MNase) is widely used to map nucleosomes. However, its aggressive endo-/exo-nuclease activities make MNase-seq unreliable for determining nucleosome occupancies, because cleavages within linker regions produce oligo- and mono-nucleosomes, whereas cleavages within nucleosomes de...
Tallennettuna:
| Julkaisussa: | Genome Biol |
|---|---|
| Päätekijät: | , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
BioMed Central
2019
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6743174/ https://ncbi.nlm.nih.gov/pubmed/31519205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1815-z |
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