Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells

BACKGROUND: Dihydroartemisinin (DHA) has been shown to exert anticancer activity through iron-dependent reactive oxygen species (ROS) generation, which is similar to ferroptosis, a novel form of cell death. However, whether DHA causes ferroptosis in glioma cells and the potential regulatory mechanis...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Chen, Yibing, Mi, Yanjun, Zhang, Xiaofei, Ma, Qian, Song, Yucen, Zhang, Liwei, Wang, Dandan, Xing, Jinliang, Hou, Benxin, Li, Haolong, Jin, Huan, Du, Wei, Zou, Zhengzhi
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6743121/
https://ncbi.nlm.nih.gov/pubmed/31519193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1413-7
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