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Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p
The heterodimeric eukaryotic Drs2p-Cdc50p complex is a lipid flippase that maintains cell membrane asymmetry. The enzyme complex exists in an autoinhibited form in the absence of an activator and is specifically activated by phosphatidylinositol-4-phosphate (PI4P), although the underlying mechanisms...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6742660/ https://ncbi.nlm.nih.gov/pubmed/31515475 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12191-9 |
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