The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension

In pulmonary hypertension vascular remodeling leads to narrowing of distal pulmonary arterioles and increased pulmonary vascular resistance. Vascular remodeling is promoted by the survival and proliferation of pulmonary arterial vascular cells in a DNA-damaging, hostile microenvironment. Here we rep...

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Udgivet i:Nat Commun
Main Authors: Wang, Yuhua, Pandey, Ram Naresh, York, Allen J., Mallela, Jaya, Nichols, William C., Hu, Yueh-Chiang, Molkentin, Jeffery D., Wikenheiser-Brokamp, Kathryn A., Hegde, Rashmi S.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742632/
https://ncbi.nlm.nih.gov/pubmed/31515519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12226-1
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