Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration

BACKGROUND: Environmental and endogenous factors under genetic predisposition are considered to initiate the human intervertebral disc (IVD) degeneration. DNA methylation is an essential mechanism to ensure cell-specific gene expression for normal development and tissue stability. Aberrant epigeneti...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ikuno, Akihiro, Akeda, Koji, Takebayashi, Shin-ichiro, Shimaoka, Motomu, Okumura, Katsuzumi, Sudo, Akihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742346/
https://ncbi.nlm.nih.gov/pubmed/31513634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0222188
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