SRC-1 Null Mice Exhibit Moderate Motor Dysfunction and Delayed Development of Cerebellar Purkinje Cells

Eitemau Tebyg

• The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development
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• Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction
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• Reply to Calderon-Montano et al.: Bufalin is a potent small molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1
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  Cyhoeddwyd: (2015)
• Moderate alcohol consumption and loss of cerebellar Purkinje cells.
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• Normal and Cancer-Related Functions of the p160 Steroid Receptor Coactivator (SRC) Family
  gan: Xu, Jianming, et al.
  Cyhoeddwyd: (2009)