Early Exposure to Common Anesthetic Agents Causes Widespread Neurodegeneration in the Developing Rat Brain and Persistent Learning Deficits

Recently it was demonstrated that exposure of the developing brain during the period of synaptogenesis to drugs that block NMDA glutamate receptors or drugs that potentiate GABA(A) receptors can trigger widespread apoptotic neurodegeneration. All currently used general anesthetic agents have either...

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Publicat a:J Neurosci
Autors principals: Jevtovic-Todorovic, Vesna, Hartman, Richard E., Izumi, Yukitoshi, Benshoff, Nicholas D., Dikranian, Krikor, Zorumski, Charles F., Olney, John W., Wozniak, David F.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2003
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741934/
https://ncbi.nlm.nih.gov/pubmed/12574416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-03-00876.2003
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