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SCH 23390: The First Selective Dopamine D(1)‐Like Receptor Antagonist
SCH 23390, the halobenzazepine (R)‐(+)‐7‐chloro‐8‐hydroxy‐3‐methyl‐1‐phenyl‐2,3,4,5‐tetrahydro‐1H–3‐benzazepine, is a highly potent and selective dopamine D(1)‐like receptor antagonist with a K (i) of 0.2 and 0.3 nM for the D(1) and D(5) dopamine receptor subtypes, respectively. In vitro, it also bi...
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| Publié dans: | CNS Drug Rev |
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| Auteur principal: | |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Blackwell Publishing Ltd
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6741643/ https://ncbi.nlm.nih.gov/pubmed/11830757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1527-3458.2001.tb00207.x |
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