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Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin
We examined whether neuronal proteinase-activated receptor-2 (PAR-2) may be involved in pruritus of human skin. The endogenous PAR-2 agonist tryptase was increased up to fourfold in atopic dermatitis (AD) patients. PAR-2 was markedly enhanced on primary afferent nerve fibers in skin biopsies of AD p...
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| 出版年: | J Neurosci |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Society for Neuroscience
2003
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6740542/ https://ncbi.nlm.nih.gov/pubmed/12867500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-15-06176.2003 |
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