Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin

We examined whether neuronal proteinase-activated receptor-2 (PAR-2) may be involved in pruritus of human skin. The endogenous PAR-2 agonist tryptase was increased up to fourfold in atopic dermatitis (AD) patients. PAR-2 was markedly enhanced on primary afferent nerve fibers in skin biopsies of AD p...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurosci
Prif Awduron: Steinhoff, Martin, Neisius, Ulrich, Ikoma, Akihiko, Fartasch, Manigé, Heyer, Gisela, Skov, Per S., Luger, Thomas A., Schmelz, Martin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2003
Pynciau:
Behavioral/Systems/Cognitive
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740542/
https://ncbi.nlm.nih.gov/pubmed/12867500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-15-06176.2003
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