Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin

We examined whether neuronal proteinase-activated receptor-2 (PAR-2) may be involved in pruritus of human skin. The endogenous PAR-2 agonist tryptase was increased up to fourfold in atopic dermatitis (AD) patients. PAR-2 was markedly enhanced on primary afferent nerve fibers in skin biopsies of AD p...

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Detalhes bibliográficos
Publicado no:J Neurosci
Principais autores: Steinhoff, Martin, Neisius, Ulrich, Ikoma, Akihiko, Fartasch, Manigé, Heyer, Gisela, Skov, Per S., Luger, Thomas A., Schmelz, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
Assuntos:
Behavioral/Systems/Cognitive
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740542/
https://ncbi.nlm.nih.gov/pubmed/12867500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-15-06176.2003
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