Impaired Repression at a 5-Hydroxytryptamine 1A Receptor Gene Polymorphism Associated with Major Depression and Suicide

Inhibition of serotonergic raphe neurons is mediated by somatodendritic 5-HT1A autoreceptors, which may be increased in depressed patients. We report an association of the C(-1019)G 5-HT1A promoter polymorphism with major depression and suicide in separate cohorts. In depressed patients, the homozyg...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Lemonde, Sylvie, Turecki, Gustavo, Bakish, David, Du, Lisheng, Hrdina, Pavel D., Bown, Christopher D., Sequeira, Adolfo, Kushwaha, Neena, Morris, Stephen J., Basak, Ajoy, Ou, Xiao-Ming, Albert, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
Assuntos:
Cellular/Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740417/
https://ncbi.nlm.nih.gov/pubmed/14507979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-25-08788.2003
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