Disregulated RhoGTPases and Actin Cytoskeleton Contribute to the Migration Defect in Lis1-Deficient Neurons

Lissencephaly is a severe brain malformation caused by impaired neuronal migration. Lis1, a causative gene, functions in an evolutionarily conserved nuclear translocation pathway regulating dynein motor and microtubule dynamics. Whereas microtubule contributions to neuronal motility are incompletely...

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Dettagli Bibliografici
Pubblicato in:J Neurosci
Autori principali: Kholmanskikh, Stanislav S., Dobrin, Joseph S., Wynshaw-Boris, Anthony, Letourneau, Paul C., Ross, M. Elizabeth
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2003
Soggetti:
Development/Plasticity/Repair
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740411/
https://ncbi.nlm.nih.gov/pubmed/14507966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-25-08673.2003
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